What are you Zaire Ebola?

Genetics: Zaire Ebola also known as EBOV, it is composed of helical RNA strand wrapped and includes many fundamental and regulatory proteins that comprising VP35, VP30, nucleoprotein and protein L in the capsid. Protein L utilizes VP30 and VP35 as cofactors that help catalyze transcription of the viral RNA along with cytosol of the host cell. The capsid is studded with 10nm spikes of viral glycoproteins and surrounded by an envelope acquired from the host cells of plasma membrane. The figure below is an excellent example of the structure:   The VP35 protein is very important for the viral RNA polymerase complex. It is also important for the function to antagonize the cellular type I interferon response, and it does so by blocking the activation of the transcription factor IRF-3.  Pathogenicity:  Zaire Ebola virus can cause a very high lethal hemorrhagic fever syndrome in animals and humans. The fast progression of the disease increases complication for the control of the disease. It is very dangerous and fatal but it is not significantly contagious.  History: Some historical background of the virus is that it was identified in the Ebola River valley during an outbreak in 1976. Statistically the outbreaks have caused mortality rates to increase from 50% to 90%. Many primary known cases were in Africa in villages and tropical rainforests. The cases of Ebola were imported into Nigeria, Senegal, Spain, Italy, Mali, USA and the UK.  Here is an overview of the locations in Africa:   Facts: When a person is recovered from the Ebola Virus, it is known to stay in semen for about 3 months.  A known cure or...

The Circle of Life

Zaire Ebola works to spread to humans and animals. It has been known that Fruit bats are natural reservoirs of the Ebola virus. The primary way for this virus to transmit is with contaminated bodily fluids.  The transmission from fruit bats to humans is presented in this image:  The virus has various mechanisms to affect the host immune system. A mechanism such as the Antibody-dependent enhancement works with the host antibodies and allows the attachment to the virus to increase the infection in the cell. Macropinocytosis is a common mechanism for a virus to infect the host cell. This allows an outward extension of the plasma membrane that allows them to fold back on themselves. The ends of the distal loop then fuse and form a macriopinsome, which means that the protein is significant for the virus to enter.  These two images present how the virus enters the cell and reproduction:  The cell is infected by the particle attaching to the surface of the cell and releasing the nucleocapsid in. The viral genomes in the nucleocapsid are negatively coiled RNA strand. The viral RNA then replicates inside the cell and becomes new virus particles. They are released out of the cell and then move onto infect other cells. These steps are then repeated.    It is known that viruses are non-living or grown on their own, thus they are unable to consume/eat. This means that viruses cannot be placed into a nutritional class or metabolic category.  Something interesting about Zaire ebola is that the virus has been found inside rodent’s internal organs and found in Central African Republic. It...

How does it look?

It is known that viruses are non-living so they cannot be prokaryotes or eukaryotes. The Zaire ebolavirus is approximately 970nm long and 80nm in diameter, it is a filamentous single-stranded RNA. It has a helical capsid surrounded inside the membrane and is a single-celled organism. They have a tubular, circular, and rod-shaped features. Zaire ebolavirus belongs to the family Filoverdae; they contain virions with outer surfaces that comprise of globular spikes derived from glycoproteins. The glycoproteins help in attachment and entering the host cell. Something interesting about the virus is that it cannot be spread through water or air.  This video gives a great description of this virus. https://youtu.be/6w-NTWU6CwY   A closer look:      Rogers, Kara. (2017,October 15). Ebolavirus. Accessed April 05,2018 https://www.britannica.com/science/ebolavirus#ref1245847   Baidya, Sankalan. (2015, January 20). 30 Interesting Ebola Facts. Accessed April 05,...

My Cute Microbe

When I went to the CDC museum, I was walking around observing the different microbes. At the corner of my eye, I spot the a big presentation of Ebola and found the microbe Zaire ebolavirus the most interesting. It has a filamentous shape and is a single-stranded RNA with a helical shape. It most commonly affects humans and nonhuman primates. This was the microbe I chose because it was the one that caught my attention the...

My experience

There are many locations that I visualized. These various places were very interesting and I obtained a great amount knowledge in each location.  Many of the places have a historical concept and give a deeper aspect to them. I personally enjoyed viewing and analyzing these locations. I learned a great amount of detail with them. I also learned more about architecture and how it works. All the problems each structure had to face were financial or public opinionated. I appreciated every factor and feature of the places. Each area had diversity and an amusing outlook. There was an importance to every location, even ones that I personally did not analyze. In my experience, architecture is an amazing concept. Learning about how and what the design are created gives a new overview of the...
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